Daily · Thursday, November 5, 2026

The AI Psych Brief

Archive

Every issue ever sent, and every one of them still on the record. The generator reads this page before it writes tomorrow’s, so no paper, no pearl, no pharmacology fact ever gets a second run. It has a very long memory and absolutely no sentimentality about it.

100 issues · nothing repeated · get the next one

September 2026

  1. No. 040Sun, Sep 6

    Impact of Vagus Nerve Stimulation on Suicidal Ideation in Markedly Treatment-Resistant Major Depression: A RECOVER Study Report

    Also
    Acute Effects of Cannabis Inhalation on Cardiac Ectopy, Physical Activity, Sleep, and Glucose
    Pearl
    Not All Validation Is the Same Intervention.DBT
  2. No. 039Sat, Sep 5

    Decades After the NIH Revitalization Act: Persistent Gaps in Diversity of US Antidepressant Trials

    Also
    Therapist Intrapersonal Factors and Rupture Repair: Professional Self-Doubt, Self-Compassion, and Repair Strategies in a Simulated Cultural Rupture Task
    Pearl
    Follow the affect, not the agenda.TFP
  3. No. 038Fri, Sep 4

    Obstetric Risk Associated With Stimulant Versus Nonstimulant Treatment During Pregnancy

    Also
    Evaluation of Interventions for Cognitive Symptoms in Long COVID: A Randomized Clinical Trial
    Pearl
    Negative capability is a discipline, not a delay.Psychodynamic
  4. No. 037Thu, Sep 3

    Open Dialogue versus treatment as usual for adults presenting in crisis to mental health services in England (the ODDESSI Trial): a multisite cluster-randomised trial

    Also
    Prediction in routine care: a naturalistic comparison of clinicians and a machine learning model for patients receiving treatment for generalised anxiety disorder
    Pearl
    Habituation was never the mechanism — expectancy violation is.CBT
  5. No. 036Wed, Sep 2

    The Typology of Common Psychiatric Disorders as Depicted by Genetic Maps: A Study Based on Swedish Population-Based Registers

    Also
    Suicidality at Epilepsy Diagnosis and Future Treatment Resistance in Adults With Focal Epilepsy
    Pearl
    Guided discovery only works if you don't already know the destination.CBT
  6. No. 035Tue, Sep 1

    Brain Morphology Mediators of the Association of Childhood Trauma With Bipolar Disorder: An International ENIGMA Bipolar Disorder Working Group Study

    Also
    Effectiveness of Atypical Antipsychotic Drugs in Patients with Alzheimer's Disease (CATIE-AD)
    Pearl
    The selected fact turns noise into a session.Psychodynamic

August 2026

  1. No. 034Mon, Aug 31

    Life's Essential 8 Cardiovascular Health and Suicide Mortality: Findings From a Nationally Representative Cohort in South Korea

    Also
    Obsessive-Compulsive Personality Disorder in Radically Open Dialectical Behavior Therapy for Treatment-Refractory Depression
    Pearl
    Apparent competence: the DBT skill that fools everyone in the room.DBT
  2. No. 033Sun, Aug 30

    Risk of Presentation for Sexual Abuse After a First Emergency Department Presentation for Self-Harm in Childhood or Adolescence

    Also
    The Effects of Antidepressants on Cardiometabolic and Other Physiological Parameters: A Systematic Review and Network Meta-Analysis
    Pearl
    Identification with the aggressor.Psychodynamic
  3. No. 032Sat, Aug 29

    Time Trends in Maternal Attention-Deficit/Hyperactivity Disorder and Medication Use in Pregnancy

    Also
    Mechanisms of Change in the Treatment of Major Depressive Disorder with Metacognitive Therapy and Behavioral Activation — A Random Intercept Cross-Lagged Panel and Mediation Analyses
    Pearl
    Reverie isn't empathy -- it's digestion.Psychodynamic
  4. No. 031Fri, Aug 28

    Use and Misuse of GLP-1 Receptor Agonists Among People With Eating Disorders

    Also
    Depression and Anxiety Associate With Adverse Cardiovascular Events via Neural, Autonomic, and Inflammatory Pathways
    Pearl
    Symbolic equation: when the metaphor stops being a metaphor.Psychodynamic
  5. No. 030Thu, Aug 27

    Integrated mental health treatment and employment services for refugees with PTSD: randomised controlled trial

    Also
    Integrated therapist and online cognitive behavioural therapy in addition to usual care versus usual care for depression in primary care in England (INTERACT): a two-group, parallel, multicentre, randomised controlled trial
    Pearl
    Optimal frustration is not empathic failure — it's how structure gets built.Psychodynamic
  6. No. 029Wed, Aug 26

    Association of Lithium Use With Suicide and Self-Harm Among Chinese Adolescents and Adults With Bipolar Disorder: A Nationwide Multicenter Retrospective Cohort Study

    Also
    Anticholinergic Drug Burden and Incident Cardiovascular Events: A Population-Based Study
    Pearl
    Splitting doesn't stay in the room — it recruits the whole team.TFP
  7. No. 028Tue, Aug 25

    Psychological and Psychosocial Interventions for People With Schizophrenia and Co-Occurring Substance Use Disorders: A Systematic Review and Meta-Analysis

    Also
    Patients' Perspective on an Optimal Therapeutic Alliance; Facilitating Engagement in Treatment of Antisocial Personality Disorder
    Pearl
    The downward arrow finds the belief the thought record can't touch.CBT
  8. No. 027Mon, Aug 24

    Connectivity- vs Scalp-Based Targeting of Accelerated Transcranial Magnetic Stimulation for Depression: A Randomized Clinical Trial

    Also
    A 14-Month Randomized Clinical Trial of Treatment Strategies for Attention-Deficit/Hyperactivity Disorder. The MTA Cooperative Group. Multimodal Treatment Study of Children with ADHD
    Pearl
    Contract-setting is the intervention before the interpretation.TFP
  9. No. 026Sun, Aug 23

    Pharmacological interventions for ADHD: a systematic review and dose-effect network meta-analysis

    Also
    Assessment of adverse effects attributed to statin therapy in product labels: a meta-analysis of double-blind randomised controlled trials
    Pearl
    Holding is a technique, not the absence of one.Psychodynamic
  10. No. 025Sat, Aug 22

    Electroencephalography Microstate Instability and Clinical Outcomes in Individuals at Clinical High Risk of Psychosis

    Also
    The Significance of Personality Disorder and Traits in Short-Term Psychodynamic and Cognitive Behavioral Therapy for Major Depression
    Pearl
    Hypermentalizing is confident, articulate, and wrong.MBT
  11. No. 024Fri, Aug 21

    Nationwide Transdiagnostic Age and Sex Patterns in Mental Disorder Disease Development

    Also
    Cognitive Rehabilitation and Functional Outcomes in Long COVID–Related Cognitive Impairment: A Randomized Clinical Trial
    Pearl
    Withdrawal ruptures and confrontation ruptures need opposite repairs.Psychodynamic
  12. No. 023Thu, Aug 20

    Effects of Brexpiprazole on Functioning in Patients With Schizophrenia Who Have Hostility and Agitation Symptoms: Post Hoc Analysis of Short- and Long-Term Trials

    Also
    Effects of Perceived Working Alliance Quality and Congruence on Naturalistic Psychotherapy Outcome: A Response Surface Analysis
    Pearl
    Irreverence is a calculated destabilization, not sarcasm.DBT
  13. No. 022Wed, Aug 19

    Adjunctive Antipsychotics in Major Depressive Disorder: A Systematic Review and Network Meta-Analysis

    Also
    Rehospitalization as a Mediator of the Association of Postoperative Delirium With Cognitive Decline in Older Adults
    Pearl
    The therapist's survival is the intervention — not the interpretation of the attack.Psychodynamic
  14. No. 021Tue, Aug 18

    Evaluating Reduced Use and Abstinence as Outcomes in Pharmacotherapy Trials for Stimulant Use Disorder: A Meta-Analysis of 12 Randomized Controlled Trials

    Also
    Predicting Premature Treatment Termination in Inpatient Psychotherapy: A Machine Learning Approach
    Pearl
    Activate the here-and-now before you illuminate it — reversing the order wastes the data.Group
  15. No. 020Mon, Aug 17

    Optimising and Personalising Task-Shared Psychosocial Interventions for Common Mental Disorders: A Bayesian Component Network Meta-Analysis of Individual Participant Data

    Also
    Lithium Plus Valproate Combination Therapy versus Monotherapy for Relapse Prevention in Bipolar I Disorder (BALANCE): A Randomised Open-Label Trial
    Pearl
    Marked mirroring is what builds affect regulation — not validation itself.MBT
  16. No. 019Sun, Aug 16

    Connectivity- vs Scalp-Based Targeting of Accelerated Transcranial Magnetic Stimulation for Depression: A Randomized Clinical Trial

    Also
    Antidepressant Treatment Duration and Risk of Sudden Cardiac Death: A Nationwide Cohort Study
    Pearl
    Epistemic trust is what determines whether insight travels home.MBT
  17. No. 018Sat, Aug 15

    Divergent Patterns of Genetic Overlap Between Severe Mental Disorders and Metabolic Markers

    Also
    Engage & Connect psychotherapy improves social reward responsivity and reduces postpartum depression
    Pearl
    Pretend mode isn't insight — it's mentalizing about nothing.MBT
  18. No. 017Fri, Aug 14

    Cognitive, Electrophysiological, and Behavioral Presentation of First-Episode Psychosis With or Without Cannabis Exposure

    Also
    Implications of the 2026 Dyslipidemia Guideline for Primary Prevention Statin Therapy
    Pearl
    Guilt replacing blame is the signal, not a symptom to fix.Psychodynamic
  19. No. 016Thu, Aug 13

    Mirtazapine for Methamphetamine Use Disorder: A Randomized Clinical Trial

    Also
    Mechanisms of Change in Day Treatment Group Schema Therapy for Severe Personality Disorders: A Multiple Baseline Single-Case Study
    Pearl
    In TFP, naming the dyad is the intervention — not just diagnosing splitting.TFP
  20. No. 015Wed, Aug 12

    Adolescent Mental Health Care and Stigma: The ARTEMIS Randomized Clinical Trial

    Also
    Adjunctive Fecal Microbiota Transplantation for Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial
    Pearl
    Opposite action for shame only works after you've sorted justified from unjustified.DBT
  21. No. 014Tue, Aug 11

    Semaglutide and Effort-Based Decision-Making in Major Depressive Disorder: A Randomized Clinical Trial

    Also
    Testing the Alliance Rupture Repair Model on Two Cases with Successful and Unsuccessful Rupture Repair: A Task Analytic Validation Study
    Pearl
    Your countertransference is either standing with the patient or standing in for someone else.Psychodynamic
  22. No. 013Mon, Aug 10

    Screening-to-Intervention Pathway for Child Anxiety Problems Alongside Usual School Practice Versus Usual School Practice Only (iCATSi2i): A Cluster-Randomised, Controlled Trial in Primary Schools in England

    Also
    Cognitive-Behavioral Therapy, Imipramine, or Their Combination for Panic Disorder: A Randomized Controlled Trial
    Pearl
    Defusion doesn't argue with the thought — it changes what the thought is made of.ACT
  23. No. 012Sun, Aug 9

    Antipsychotic Efficacy and Safety of LB-102 in the Treatment of Adults With Acute Schizophrenia: A Randomized Clinical Trial

    Also
    Neuropsychiatric Outcomes With Tirzepatide, Semaglutide, and Other GLP-1 Receptor Agonists
    Pearl
    Triangulation isn't the problem — it's the map of who's not differentiated.Family
  24. No. 011Sat, Aug 8

    Intermittent Theta Burst Stimulation of the Dorsomedial Prefrontal Cortex and Expectancy-Driven Placebo Mood Effects: A Randomized Clinical Trial

    Also
    Effects of Short-Term Versus Long-Term Mentalization-Based Therapy on Psychiatric Symptoms in Outpatients With Borderline Personality Disorder: Exploratory Results From a Randomized Clinical Trial
    Pearl
    Working through is not an insight — it's tolerating the same person being good and disappointing, over and over.Psychodynamic
  25. No. 010Fri, Aug 7

    Circadian Rhythm Stabilization App to Prevent Mood Episode Recurrence in Patients With Mood Disorders: A Multicenter, Double-Blind, Sham-Controlled, Randomized Clinical Trial

    Also
    Prolonged Short Sleep and Its Effect on Body Weight and Composition: A Pooled Analysis of Randomized Trials
    Pearl
    In IPT, the problem area you choose is the treatment — pick the wrong one and the technique stops working.IPT
  26. No. 009Thu, Aug 6

    Low-Dose Buprenorphine Following Ketamine Treatment for Suicidal Ideation in Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial

    Also
    Dialectical Behavior Therapy vs Schema Therapy for Patients With Borderline Personality Disorder: The BOOTS Multicenter Randomized Clinical Trial
    Pearl
    Analyze the retreat, not the thing retreated from.Psychodynamic
  27. No. 008Wed, Aug 5

    The Efficacy and Safety of Cannabinoids for the Treatment of Mental Disorders and Substance Use Disorders: A Systematic Review and Meta-Analysis

    Also
    Multidomain Lifestyle Intervention for the Prevention of Cognitive Decline in At-Risk Older Adults in Latin America (LatAm-FINGERS): A Single-Blind, Multicentre, Randomised Controlled Trial
    Pearl
    Neutrality is not a flat affect — and the real relationship is not a lapse in technique.Psychodynamic
  28. No. 007Tue, Aug 4

    Interleukin 6 as a Treatment Target for Depression: A Proof-of-Concept Randomized Clinical Trial

    Also
    Baseline Social Inhibition and Age as Moderators of the Within-Patient Alliance-Outcome Link in Treatments for Depression
    Pearl
    A behavioral experiment that cannot fail has not tested anything.CBT
  29. No. 006Mon, Aug 3

    Mapping 2-Year Psychiatric and Neurologic Risks After Infections Across Body Systems and Age Groups

    Also
    Ceperognastat in Early Symptomatic Alzheimer Disease: A Randomized Clinical Trial
    Pearl
    The negative therapeutic reaction: when getting better is the threat.Psychodynamic
  30. No. 005Sun, Aug 2

    Personalized fMRI-Guided TMS Targeting the Threat Neurocircuitry in PTSD: A Randomized Clinical Trial

    Also
    Session-Level Emotional Processing and Subsequent Somatic Symptom Change in Online ISTDP for Treatment-Resistant Somatic Symptom Disorder: A Lagged Within-Person Secondary Analysis
    Pearl
    Psychic equivalence is not a metaphor problem — it is why your reassurance made things worse.MBT
  31. No. 004Sat, Aug 1

    Oral Semaglutide for Alcohol Use Disorder: A Randomized Clinical Trial

    Also
    Patient-Centered Prescription Opioid Tapering Methods: A Randomized Clinical Trial
    Pearl
    Enactments are not mistakes you avoided badly — they are the material arriving in the only form it can take.Psychodynamic

July 2026

  1. No. 003Fri, Jul 31

    Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy versus Right Unilateral Ultra-Brief Electroconvulsive Therapy in Depression (CREST-MST): A Randomised, Double-Blind, Non-Inferiority Trial in Canada and the USA

    Also
    Embodied Movement Markers of Alliance Ruptures in Psychotherapy: A Machine Learning Study
    Pearl
    Behavioral chain analysis is not a history — it is a search for the link you can actually change.DBT
  2. No. 002Thu, Jul 30

    Clozapine After 1 Failed Antipsychotic Drug Trial in First-Episode Psychosis: A Randomized Clinical Trial

    Also
    Venous Thromboembolism After Mechanical Restraint in Psychiatric Hospitals: Population Based Cohort and Self-Controlled Case Series Study
    Pearl
    Clarification, confrontation, interpretation — the sequence is the technique.TFP
  3. No. 001Wed, Jul 29

    Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression: The EPISODE Randomized Clinical Trial

    Also
    Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis (ESSENCE)
    Pearl
    Projective identification, and what containment actually requires of you.Psychodynamic
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