Daily · Thursday, November 5, 2026

The AI Psych Brief

Archive

Every issue ever sent, and every one of them still on the record. The generator reads this page before it writes tomorrow’s, so no paper, no pearl, no pharmacology fact ever gets a second run. It has a very long memory and absolutely no sentimentality about it.

100 issues · nothing repeated · get the next one

November 2026

  1. No. 100Thu, Nov 5

    Instrumental Support Calls vs. Caring Contacts Texts to Prevent Suicide in Adolescents and Adults: The SPARC Randomized Clinical Trial

    Also
    Efficacy of measurement-based care (MBC) in routine child and youth behavioral therapy: A pragmatic randomized controlled trial
    Pearl
    In DBT, when validation stalls, go irreverent - an off-beat response can unstick the session.DBT
  2. No. 099Wed, Nov 4

    Prefrontal Cortical Changes With Mindfulness-Oriented Recovery Enhancement in Opioid Use Disorder: A Randomized Clinical Trial

    Also
    Preoperative Intranasal Oxytocin and Probable Acute Stress Disorder After Traumatic Fracture Surgery: A Randomized Clinical Trial
    Pearl
    Ask for associations to a dream before you offer it a meaning.Psychodynamic
  3. No. 098Tue, Nov 3

    Bilateral Theta-Burst Stimulation of Dorsolateral Prefrontal Cortex Regions for Late-Life Depression: A Randomized, Sham-Controlled Clinical Trial

    Also
    The working alliance predicts session-by-session change in problems and functioning in short-term psychodynamic psychotherapy
    Pearl
    In TFP, the contract exists so the breach can be read.TFP
  4. No. 097Mon, Nov 2

    Clinical and genetic correlates of a circadian subtype of depression in the Australian Genetics of Depression Study

    Also
    QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients
    Pearl
    Containment means handing the feeling back digested, not returned unopened.Psychodynamic
  5. No. 096Sun, Nov 1

    Effect of pharmacological treatment of attention-deficit hyperactivity disorder on academic performance: registry-based population study

    Also
    Timing of Initiation of Methadone Take-Home Dosing
    Pearl
    In TFP, confront the contradiction the patient isn't bothered by.TFP

October 2026

  1. No. 095Sat, Oct 31

    Change in HbA1c and weight after initiation of antipsychotic treatment in people with severe mental illness in England: an individual-level interrupted time-series analysis

    Also
    What happens after being not-on-track? Patterns of change, profiles and prediction of at-risk patients
    Pearl
    When the patient agrees with every interpretation, interpret the agreement.Psychodynamic
  2. No. 094Fri, Oct 30

    GLP-1 Receptor Agonists and Risk of Kidney Replacement Therapy and Health Care Utilization in Bipolar Disorder With Chronic Kidney Disease

    Also
    Comparative Effectiveness of Phenobarbital vs Diazepam for Alcohol Withdrawal Syndrome
    Pearl
    When you prescribe and do therapy, the prescription joins the transference.Psychodynamic
  3. No. 093Thu, Oct 29

    Clinical and Cognitive Outcomes Comparing Right Unilateral Ultrabrief Electroconvulsive Therapy Versus Magnetic Seizure Therapy for Bipolar Depression: The CORRECT-BD Trial

    Also
    Using machine learning to predict long-term treatment outcomes in psychotherapy for personality disorders
    Pearl
    An enactment you have already joined is better material than one you avoided.Psychodynamic
  4. No. 092Wed, Oct 28

    Multimodal Machine Learning–Based Prediction of Relapse in Major Depressive Disorder

    Also
    Smoking Cessation Among Underserved Patients Referred for Lung Cancer Screening: A Randomized Clinical Trial
    Pearl
    Concordant or complementary: name which identification you are in before you interpret.Psychodynamic
  5. No. 091Tue, Oct 27

    Reducing suicidal ideation through protective media content in India: randomised controlled trial

    Also
    Patients' General Versus Personal Expectations About Psychotherapy Change Processes
    Pearl
    In psychic equivalence, don't argue with the feeling - slow down until it can be a feeling again.MBT
  6. No. 090Mon, Oct 26

    Angiotensin-Converting Enzyme in Patients With Early-Stage Psychosis

    Also
    Neonatal Abstinence Syndrome after Methadone or Buprenorphine Exposure (the MOTHER trial)
    Pearl
    When a patient gets worse right after getting better, look at what the improvement cost them.Psychodynamic
  7. No. 089Sun, Oct 25

    Long-term health, criminal justice, and socioeconomic outcomes among people subject to compulsory mental health care in Norway: a nationwide registry cohort study

    Also
    Benzodiazepine Use Early in Pregnancy and Risk for Congenital Malformations
    Pearl
    In MBT, when mentalizing collapses, stop and rewind to the moment before it broke.MBT
  8. No. 088Sat, Oct 24

    Caring Letters and Suicide Mortality Among US Veterans Who Contacted the Veterans Crisis Line: A Prespecified Secondary Analysis

    Also
    Long-Term Psychodynamic Psychotherapy for Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
    Pearl
    The patient's response to an interpretation is the next piece of transference.Psychodynamic
  9. No. 087Fri, Oct 23

    GLP-1 receptor agonist initiation and risk of psychiatric hospitalisation and emergency department presentation in adults with schizophrenia and type 2 diabetes in the USA: an observational cohort study using electronic health records data

    Also
    Earlier Disclosure of Blood-Based Biomarkers, Diagnostic Certainty, and Clinical Management: A Randomized Clinical Trial
    Pearl
    In supportive therapy, leave a defense alone if it is still working.Supportive
  10. No. 086Thu, Oct 22

    Effectiveness of rTMS vs. Pharmacotherapy in Late-Life Treatment-Resistant Depression: An Observational Study of Individual Participant Data From Two Randomized Clinical Trials

    Also
    Dynamic change patterns in suicidal ideation differ in Brief Cognitive Behavioral Therapy (BCBT) and Present-Centered Therapy (PCT)
    Pearl
    When you are the good therapist and the last one was the bad one, you are being cast.TFP
  11. No. 085Wed, Oct 21

    Online Sports Betting Legalization and Behavioral Health Care Use

    Also
    Revascularization of Asymptomatic Carotid Artery Stenosis: Cognitive Results of the CREST-2 Randomized Trials
    Pearl
    Interpret shame from beside the patient, not from above.Psychodynamic
  12. No. 084Tue, Oct 20

    Individualized Connectivity-Guided Versus Conventional Targeting of Accelerated Theta-Burst Stimulation in Depression: A Randomized, Double-Blind, Parallel-Design Trial

    Also
    A randomized controlled trial of regulation-focused psychotherapy for children with externalizing disorders
    Pearl
    With a paranoid patient, make the interpretation about you, not them.Psychodynamic
  13. No. 083Mon, Oct 19

    Impact of Cannabis Use on Time to Psychiatric Rehospitalization in Young Adults With Bipolar and Psychotic Disorders: A Survival Analysis

    Also
    Depressive Symptoms and Health-Related Quality of Life: The Heart and Soul Study
    Pearl
    Identification with the aggressor: the patient may be showing you what was done to them.Psychodynamic
  14. No. 082Sun, Oct 18

    Connectomic Determinants of Subcallosal Cingulate Deep Brain Stimulation for Depression

    Also
    Interventions to Improve Outpatient Follow-up for Hospitalized Patients With Alcohol Use Disorder: A Systematic Review
    Pearl
    Hate in the countertransference has to be owned before it stops leaking.Psychodynamic
  15. No. 081Sat, Oct 17

    Characterizing Artificial Intelligence Psychosis in a Large Medical Setting

    Also
    Shedding light on the efficacy of psychodynamic treatment targeting depression for patients with comorbid narcissistic personality disorder
    Pearl
    A silence has a transference before it has a meaning.Psychodynamic
  16. No. 080Fri, Oct 16

    Psychological Interventions Targeting Auditory Hallucinations in Persons With Psychotic Disorders: A Systematic Review and Meta-Analysis

    Also
    Dexmedetomidine Use and Intensive Care Unit Admissions for Patients With Medetomidine Withdrawal
    Pearl
    Opposite action only works when the emotion doesn't fit the facts.DBT
  17. No. 079Thu, Oct 15

    Incidence of systemic physical multimorbidity among people with schizophrenia-spectrum or bipolar-spectrum disorders compared with age-matched and sex-matched individuals in Queensland, Australia: a statewide, hospital cohort study

    Also
    Clinical Characteristics, Neuroimaging Findings, and Mortality in Korsakoff Syndrome
    Pearl
    Working through: an interpretation that lands once has to be found again.Psychodynamic
  18. No. 078Wed, Oct 14

    Attention-Deficit/Hyperactivity Disorder and Late-Life Cognitive Impairment

    Also
    Mapping negative experiences in psychotherapy: A network analysis
    Pearl
    The doorknob disclosure belongs to the next session, not the next ten minutes.Psychodynamic
  19. No. 077Tue, Oct 13

    Pharmacotherapies for Co-Occurring Stimulant Use Disorder and Attention-Deficit/Hyperactivity Disorder: A Network Meta-Analysis

    Also
    Antiseizure medication use in pregnancy and the risk of poor fetal growth in the EURAP international registry: a prospective cohort study
    Pearl
    When a patient asks about your life, explore the question before you answer it.Psychodynamic
  20. No. 076Mon, Oct 12

    National Trends in Benzodiazepine Dispensing

    Also
    Evaluating Three Treatments for Borderline Personality Disorder: A Multiwave Study
    Pearl
    A patient's gift is an association — receive it before you decide what to do with it.Psychodynamic
  21. No. 075Sun, Oct 11

    Sex differences in the efficacy, acceptability, and tolerability of antipsychotics in people with acute schizophrenia: individual participant data pairwise, dose-response, and network meta-analyses

    Also
    Trust and respect declines and recoveries in psychotherapy: Clinical impact of relational feedback
    Pearl
    Erotic transference is a message to decode, not a feeling to manage away.Psychodynamic
  22. No. 074Sat, Oct 10

    Glucagon-Like Peptide 1 Receptor Agonists, Mortality, and Cardiovascular Outcomes in Serious Mental Illness

    Also
    Hearing Intervention for Older Adults With Mild Cognitive Impairment: The CHOICE Randomized Clinical Trial
    Pearl
    In MBT, move the patient to the pole they're stuck at the opposite end of.MBT
  23. No. 073Fri, Oct 9

    Incidence of clozapine-associated neutropenia in patients with schizophrenia: 20-year population-based study in Hong Kong

    Also
    Predicting patient outcomes from initial in-session interactions within cognitive behavioral therapy and person-centered experiential therapy for severe depression
    Pearl
    The late arrival is a message about the frame, not a scheduling problem.Psychodynamic
  24. No. 072Thu, Oct 8

    A Digital Therapeutic Intervention for Negative Symptoms of Schizophrenia: A Randomized Clinical Trial

    Also
    Prenatal Acetaminophen (Paracetamol) Use and the Risk of Autism and/or Attention-Deficit/Hyperactivity Disorder Among Sibling-Matched Cohorts
    Pearl
    In TFP, the dyad matters less than the moment it flips.TFP
  25. No. 071Wed, Oct 7

    Reducing Ultraprocessed Foods From the Diets of Patients With Depression: A Pilot Crossover Trial

    Also
    Transformative pathways: shame and fear of compassion as potential mechanisms of change in psychotherapy
    Pearl
    In supportive therapy, praise has to be accurate to do any work.Supportive
  26. No. 070Tue, Oct 6

    Structural brain changes and clinical outcomes of patients with NMDA receptor encephalitis in Germany: a cross-sectional study

    Also
    Telehealth Treatment of Anxiety in Patients With Low-Risk Chest Pain in the Emergency Department: The PACER Randomized Clinical Trial
    Pearl
    When the staff start fighting, the patient's inner world has moved onto the unit.Psychodynamic
  27. No. 069Mon, Oct 5

    Changes in Genetic Contributions to ASD and ADHD by Year of Diagnosis

    Also
    Randomized, placebo-controlled trial of exposure and ritual prevention, clomipramine, and their combination in the treatment of obsessive-compulsive disorder
    Pearl
    Termination reopens every earlier separation — set the date early and watch what comes back.Psychodynamic
  28. No. 068Sun, Oct 4

    Comparative effectiveness of mood stabiliser monotherapy versus second-generation antipsychotic monotherapy versus combination therapy for continuation and maintenance treatment after a first episode of psychotic mania in North America, Chile, and Spain: a target trial emulation using data from the BD-CAUSAL Collaboration

    Also
    Toward Personalized Psychotherapy in Anorexia Nervosa: Evidence from Long-Term Moderator Analyses of the ANTOP Study
    Pearl
    In TFP, go to the channel that's carrying the most.TFP
  29. No. 067Sat, Oct 3

    Relapse trajectories and antipsychotic discontinuation in schizophrenia from individual participant data of five trials from the Yale Open Data Access database: a meta-analysis

    Also
    Oveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials
    Pearl
    Boredom in the session is a clinical finding, not a mood.Psychodynamic
  30. No. 066Fri, Oct 2

    Comparative efficacy of antipsychotics for reducing aggression in schizophrenia: systematic review and network meta-analysis

    Also
    The efficacy of modified psychodynamic psychotherapy for patients with schizophrenia-spectrum disorders in Germany: a prospective, single-centre, assessor-blinded, parallel-group, randomised controlled trial
    Pearl
    Pretend mode sounds like insight until you notice nothing moves.MBT
  31. No. 065Thu, Oct 1

    Prior Sexual Violence, PTSD Symptoms, and Recovery Trajectories After New Trauma

    Also
    QTc changes and early major adverse cardiovascular events associated with antidepressant treatment for major depressive disorder in adults: individual participant data network meta-regression of double blind randomised trials
    Pearl
    Transference work helps most where it looks riskiest.Psychodynamic

September 2026

  1. No. 064Wed, Sep 30

    Brain lithium temporospatial kinetics in bipolar disorder: a repeated-measures 7Li MRI study of dosing regimens in Germany

    Also
    Treatment dose and reliable change in trauma-focused therapy for comorbid PTSD and MDD
    Pearl
    Interpret in displacement before you interpret in the transference.Psychodynamic
  2. No. 063Tue, Sep 29

    Association between CYP2D6 and CYP2C19 genotypes and venlafaxine treatment failure: a retrospective study on two cohorts from Norway and the UK

    Also
    Exploring high priority potentially inappropriate prescribing cascades in older adults: population level retrospective cohort study
    Pearl
    Analyze the defense before the content it is hiding.Psychodynamic
  3. No. 062Mon, Sep 28

    Structural Brain Correlates of Bulimia Nervosa Diagnosis and Symptom Severity: A Coordinated ENIGMA Eating Disorders Working Group Analysis

    Also
    Treatment of Depression in Patients With Alcohol or Other Drug Dependence: A Meta-Analysis
    Pearl
    A Role Dispute's Stage — Not Its Content — Tells You Which Technique to Use.IPT
  4. No. 061Sun, Sep 27

    A Phase 2 Randomised, Double-Blind, Placebo-Controlled Trial of Emestedastat in Patients With Major Depressive Disorder and Cognitive Impairment (XanaCIDD Trial)

    Also
    Cognitive Mechanisms of Change in OCD: Inferential Confusion, Obsessive Beliefs, and Mindfulness Across Three Randomized Treatments
    Pearl
    Interpersonal Deficits Treats Isolation as the Illness, Not Its Symptom.IPT
  5. No. 060Sat, Sep 26

    Psychotherapy for Impact of Killing During War: A Randomized Clinical Trial

    Also
    Neurological Manifestations in Adult Survivors of Ebola Virus Disease
    Pearl
    Chain Analysis Finds the Vulnerability, Not Just the Trigger.DBT
  6. No. 059Fri, Sep 25

    Convergence of TMS Sites and Lesion Locations Associated With Nicotine Addiction Improvement on a Common Brain Circuit

    Also
    Moderating Factors for the Effectiveness of Brief Psychological Intervention for People With Probable Personality Disorder: Secondary Analysis of Data From the SPS Trial
    Pearl
    Grandiosity Is Load-Bearing, Not Just Obnoxious.Psychodynamic
  7. No. 058Thu, Sep 24

    Convergent Network Localization of Brain Stimulation Targets for Trait Anxiety

    Also
    Impact of Cortisol Circadian Rhythm on Psychological Well-Being in Treated Cushing Syndrome: A Cross-Sectional Study
    Pearl
    Affect Focus Anchors the Session Before Content Does.MBT
  8. No. 057Wed, Sep 23

    Predicting Long-Term Poor Outcomes in Individuals at Clinical High Risk for Psychosis Using Real-World Clinical Data: The OASIS1000 Prospective Study

    Also
    Potential Mechanisms of Change in Virtual Reality-Based CBT and Standard CBT for Schizophrenia-Related Paranoia: A Mediation Analysis From the FaceYourFears Trial
    Pearl
    Renegotiating the Contract Is Itself an Intervention, Not an Administrative Reset.TFP
  9. No. 056Tue, Sep 22

    Comparison of Long-Acting Injectable and Oral Antipsychotics in Bipolar Disorder

    Also
    Takotsubo Syndrome Diagnosis: The Biomarker-Based BioTAK Score
    Pearl
    The Total Situation Is the Interpretation, Not Just What's Said.Psychodynamic
  10. No. 055Mon, Sep 21

    Adolescent Peers' Diagnoses and Genetic Predispositions and Subsequent Risk of Mental Disorders

    Also
    Behavioral and Pharmacological Therapies for Late-Life Insomnia: A Randomized Controlled Trial
    Pearl
    Role Transition Grief Has to Be Mourned Before It Can Be Solved.IPT
  11. No. 054Sun, Sep 20

    Ketamine Infusions and Rapid Reduction of Suicidal and Depressive Symptoms in Major Depressive Episode: A Systematic Review and Meta-Analysis

    Also
    Is More Treatment Truly Better? A Meta-Analysis of the Dose-Response Effect of Individual Psychotherapy for Treatment of Generalized Anxiety Disorder in Adults
    Pearl
    Container-Contained: The Anxiety Has to Land Somewhere Before It Can Be Thought.Psychodynamic
  12. No. 053Sat, Sep 19

    Neurometabolites and Antipsychotic Response in Psychosis: A Mega-Analysis

    Also
    The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID: An Adaptive Randomized Trial
    Pearl
    Communication Analysis Finds the Gap Insight Alone Can't.IPT
  13. No. 052Fri, Sep 18

    The Reinforcement Effect of Social Media Likes in Depression

    Also
    A Randomized Controlled Trial Testing the Effects of Sequential Psychotherapy in Depression: Changing Therapist, or Both Therapist and Method?
    Pearl
    An Enactment Is Data, Not a Failure of Technique.Psychodynamic
  14. No. 051Thu, Sep 17

    Pharmacological Interventions for Weight Reduction in Patients With Schizophrenia Treated With Antipsychotics: A Systematic Review and Network Meta-Analysis

    Also
    Selective Serotonin Reuptake Inhibitors and Bleeding Risk in Patients Undergoing PCI on Dual Antiplatelet Therapy: A Retrospective Cohort Study
    Pearl
    Therapeutic Neutrality Was Never the Absence of a Relationship.Psychodynamic
  15. No. 050Wed, Sep 16

    Gastrointestinal Interoception and Relapse in Anorexia Nervosa

    Also
    Collaborative Working Models of Alliance Rupture Repair: A Theory-Building Case Study
    Pearl
    TFP's Clarification-Confrontation-Interpretation Sequence Isn't Optional Order.TFP
  16. No. 049Tue, Sep 15

    Trauma-Focused Therapy Integrated With CBT for Psychosis in People With PTSD and Psychosis: The STAR Trial

    Also
    Antipsychotic Exposure and Pharmacologically Treated Type 2 Diabetes in Dutch Youths
    Pearl
    The Negative Therapeutic Reaction: When Getting Better Feels Like a Threat.Psychodynamic
  17. No. 048Mon, Sep 14

    GH001 vs Placebo in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial

    Also
    Does Congruence Between Therapist and Patient in Session-by-Session Bond Ratings Predict Change in Symptoms?
    Pearl
    Safety Behaviors Don't Just Coexist with the Fear — They Manufacture Its Survival.CBT
  18. No. 047Sun, Sep 13

    Dialectical Behavior Therapy Versus Serotonin Reuptake Inhibitor Treatment for Suicidal Behavior in Borderline Personality Disorder: A Randomized Controlled Trial

    Also
    Efficacy and Target Engagement of Dopamine Agonist Pramipexole for Anhedonic Depression: A Randomized Placebo-Controlled Trial
    Pearl
    Missing-Links Analysis: Before Assuming "Won't," Rule Out "Can't".DBT
  19. No. 046Sat, Sep 12

    Efficacy and Safety of the Neuroplastogen TSND-201 for the Treatment of PTSD: A Randomized Clinical Trial

    Also
    Therapeutic Alliance and Suicidal Ideation During Therapy and the Role of Racial/Ethnic Identity
    Pearl
    An Interpretation That Explains Everything Leaves the Patient Nothing to Discover.Psychodynamic
  20. No. 045Fri, Sep 11

    Heart Rate Variability Biofeedback for Substance Use Disorder: A Randomized Clinical Trial

    Also
    Longitudinal Risk for Suicidal Self-Directed Violence Among Veterans With Cancer
    Pearl
    When Mentalizing Breaks Down, Rewind the Tape — Don't Push Forward.MBT
  21. No. 044Thu, Sep 10

    Efficacy and Tolerability of Seven Antipsychotic Drugs in Acutely Ill Patients With Schizophrenia: A Randomized, Multicenter, Assessor-Blinded Trial

    Also
    Supervised Therapist and Supervisor Impact on Client Therapy Outcomes
    Pearl
    Follow the Affectively Dominant Theme, Not the Stated Topic.TFP
  22. No. 043Wed, Sep 9

    Serial Ketamine Infusions for Treatment-Resistant Bipolar Depression: A Randomized Clinical Trial

    Also
    Benzodiazepine Prescriptions to Older Adults in the United States, 2015 to 2024
    Pearl
    Concordant or Complementary — Your Countertransference Is Telling You Which Character You've Been Cast As.Psychodynamic
  23. No. 042Tue, Sep 8

    A Pragmatic SMART Study of Medication and CBT Sequencing in Pediatric Anxiety Disorders: A Randomized Clinical Trial

    Also
    Global Burden of Disease Attributable to Mental and Substance Use Disorders: Findings from the Global Burden of Disease Study 2010
    Pearl
    Projective Identification Is Communication Before It's Defense.Psychodynamic
  24. No. 041Mon, Sep 7

    Trends in the Prevalence and Severity of Alcohol and Cannabis Use Disorders Among US Adults

    Also
    Personalized and Optimal Treatment Estimated by a Value-Search Method in a Randomized Clinical Trial With Psychodynamic Versus Cognitive Behavioral Therapy for Depression
    Pearl
    Introjective and Anaclitic Depression Aren't the Same Illness.Psychodynamic
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